Neurovascular Coupling and Cerebrovascular Diseases


Neurovascular coupling plays a crucial role in maintaining the balance between cerebral blood flow and neuronal activity in the brain. It refers to the tight interaction between neurons, astrocytes, and blood vessels, ensuring an adequate oxygen and nutrient supply to active brain regions. Dysfunction in neurovascular coupling has been implicated in various cerebrovascular diseases, including ischemic stroke, hemorrhagic stroke, and vascular dementia. Impaired coupling can lead to compromised blood flow regulation, inadequate oxygenation, and neuronal damage. Understanding the mechanisms underlying neurovascular coupling and its disruption in cerebrovascular diseases is vital for developing targeted interventions to restore proper brain perfusion and preserve neuronal function, ultimately improving outcomes for patients affected by these conditions.


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